Procédés de caractérisation de l'hépatotoxicité en fonction du temps

Methods for characterizing time-based hepatotoxicity

Abstract

Methods of characterizing the time-based hepatotoxicity of a test compound are provided. In some embodiments the provided methods allow prediction of the hepatotoxic potential of a test compound in a way that is improved relative to that acheivable with prior art methods. In some embodiments the methods may be used to quantify the relationship between measurements or estimates of toxicity made at different, successive points in time, to provide highly meaningful tool to assess the likely in vivo hepatotoxicity of test compounds in vivo.
L'invention concerne des procédés de caractérisation de l'hépatotoxicité en fonction du temps d'un composé d'essai. Selon certains modes de réalisation, les procédés selon l'invention permettent de prévoir le potentiel hépatotoxique d'un composé d'essai d'une manière qui est améliorée par rapport à celui pouvant être obtenu par les procédés de la technique antérieure. Selon certains modes de réalisation, les procédés peuvent être utilisés pour quantifier la relation entre des mesures ou des estimations de toxicité effectuées à des moments différents, successifs dans le temps, pour procurer un outil très efficace afin d'évaluer la probabilité d'une hépatotoxicité in vivo de composés d'essai in vivo.

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