Polypeptides contenant fc présentant une liaison accrue à fcgammariib

Fc CONTAINING POLYPEPTIDES HAVING INCREASED BINDING TO FcGammaRIIB

Abstract

The present invention is directed to methods and compositions for the production of Fc-containing polypeptides which are useful as human or animal therapeutic agents, and which comprise increased anti-inflammatory properties and improved FcyRIIb binding.
La présente invention concerne des méthodes et des compositions pour la production de polypeptides contenant Fc qui sont utiles en tant qu'agents thérapeutiques humains ou animaux, et qui comprennent des propriétés anti-inflammatoires accrues et une liaison améliorée à FcyRIIb.

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (5)

    Publication numberPublication dateAssigneeTitle
    US-2012009188-A1January 12, 2012Lfb BiotechnologiesOptimized fc variants
    US-2013202606-A1August 08, 2013Macrogenics, Inc.Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same
    WO-2006053301-A2May 18, 2006Xencor, Inc.Variants fc presentant une liaison modifiee au fcrn
    WO-2012162277-A1November 29, 2012Merck Sharp & Dohme Corp.METHOD FOR PREPARING Fc-CONTAINING POLYPEPTIDES HAVING IMPROVED PROPERTIES
    WO-2013095966-A1June 27, 2013The Rockefeller UniversityNon-sialylated anti-inflammatory polypeptides

NO-Patent Citations (0)

    Title

Cited By (1)

    Publication numberPublication dateAssigneeTitle
    WO-2017103001-A3August 10, 2017INSERM (Institut National de la Santé et de la Recherche Médicale), Assistance Publique-Hôpitaux De Paris (Aphp), Université Paris-Est Créteil Val De MarneDiagnostic markers of immunosenescence and methods for determining the susceptibility to nosocomial infections